Chemigenetic Biosensors

Fluorescent biosensors allow us to perform dynamic measurements in living cells and have revolutionized the spatiotemporal investigation of living cells. However, to keep up with the ever-increasing demands to study dynamic biological processes in more depth, biosensors with enhanced capabilities need to be developed. Chemigenetic biosensors, a relatively new class of biosensors that combine synthetic fluorophores with genetically encodable components like self-labeling protein tags, are ideally suited to tackle these challenges. We are hence focusing our research efforts to expand the repertoire of chemigenetic biosensors. We harness their unique properties to generate biosensors for previously inaccessible targets and make biosensors available with enhanced properties.