Publications

2024

Farrants, H., Shuai, Y., Lemon, W. C., Monroy Hernandez, C., Zhang, D., Yang, S., Patel, R., Qiao, G., Frei, M. S., Plutkis, S. E., Grimm, J. B., Hanson, T. L., Tomaska, F., Turner, G. C., Stringer, C., Keller, P. J., Beyene, A. G., Chen, Y., Liang, Y., Lavis, L. D., Schreiter, E. R., "A modular chemigenetic calcium indicator for multiplexed in vivo functional imaging" Nat Methods 2024. external page doi: 10.1038/s41592-024-02411-6
 

Frei, M. S., Sanchez, S. A., Liu, L., Schneider, F., Wang, Z., Hakozaki, H., Li, Y., Lyons, A. C., Rohm, T. V., Olefsky, J. M., Shi, L., Schöneberg, J., Fraser, S. E., Mehta, S., Wang, Y., Zhang, J., "Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging" bioRxiv 2024. external page doi: 10.1101/2024.02.10.579766

Frei, M. S., Mehta, S., Zhang, J., "Next-generation genetically encoded fluorescent biosensors illuminate cell signaling and metabolism" Annu. Rev. Biophys. 2024, 53, 275-297. external page doi: 10.1146/annurev-biophys-030722-021359

2023

Hellweg, L., Edenhofer, A., Barck, L., Huppertz, M.-C., Frei, M. S., Tarnawski, M., Bergner, A., Koch, B., Johnsson, K., Hiblot, J., “A general method for the development of multicolor biosensors with large dynamic ranges” Nat. Chem. Biol. 2023, 19, 1147-1157. external page doi: 10.1038/s41589-023-01350-1

Xue, L., Schnacke, P., Frei, M. S., Koch, B., Hiblot, J., Wombacher, R., Fabritz, S., Johnsson, K. “Probing coenzyme A homeostasis with semisynthetic biosensors” Nat. Chem. Biol. 2023, 19, 346–355. external page doi: 10.1038/s41589-022-01172-7

Kompa, J., Bruins, J., Glogger, M., Wilhelm, J., Frei, M. S., Tarnawski, M., D’Este, E., Heilemann, M., Hiblot, J., Johnsson, K. “Exchangeable HaloTag ligands for super-resolution fluorescence microscopy” J. Am. Chem. Soc. 2023, 145, 3075–3083. external page doi: 10.1021/jacs.2c11969
 

2022

Frei, M. S.*, Koch, B., Hiblot, J., Johnsson, K.* “Live-cell fluorescence lifetime multiplexing using synthetic fluorescent probes” ACS Chem. Biol. 2022, 17, 1321–1327.  external page doi: 10.1021/acschembio.2c00041 * Co-corresponding

Frei, M. S., Tarnawski, M., Roberti, M. J., Koch, B., Hiblot, J., Johnsson, K. “Engineered HaloTag variants for fluorescence lifetime multiplexing” Nat. Methods 2022, 19, 65–70. external page doi: 10.1038/s41592-021-01341-x
 

2019

Frei, M. S., Hoess, P., Lampe, M., Nijmeijer, B., Kueblbeck, M., Ellenberg, J., Wadepohl, H., Ries, J., Pitsch, S., Reymond, L., Johnsson, K. “Photoactivation of silicon rhodamines via a light-induced protonation“ Nat. Commun. 2019, 10, 4580. external page doi: 10.1038/s41467-019-12480-3

Wang, L., Frei, M. S., Salim, A., Johnsson, K. “Small-Molecule Fluorescent Probes for Live-Cell Super-Resolution Microscopy” J. Am. Chem. Soc. 2019, 141, 2770–2781. external page doi: 10.1021/jacs.8b11134

2017

Schwertz, G., Frei, M. S., Witschel, M. C., Rottmann, M., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schäfer, A., Aponte, R. A., Trapp, N., Mark, K., Chaiyen, P., Diederich, F. “Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs” Chem. Eur. J. 2017, 23, 14345–14357. external page doi: 10.1002/chem.201703244