Publications
2024
Frei, M. S., Sanchez, S. A., Liu, L., Schneider, F., Wang, Z., Hakozaki, H., Li, Y., Lyons, A. C., Rohm, T. V., Olefsky, J. M., Shi, L., Schöneberg, J., Fraser, S. E., Mehta, S., Wang, Y., Zhang, J., "Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging" bioRxiv 2024. external pagedoi: 10.1101/2024.02.10.579766call_made
Frei, M. S., Mehta, S., Zhang, J., "Next-generation genetically encoded fluorescent biosensors illuminate cell signaling and metabolism" Annu. Rev. Biophys. 2024, 53, 275-297. external pagedoi: 10.1146/annurev-biophys-030722-021359call_made
2023
Farrants, H., Shuai, Y., Lemon, W. C., Monroy Hernandez, C., Yang, S., Patel, R., Qiao, G., Frei, M. S., Grimm, J. B., Hanson, T. L., Tomaska, F., Truner, G. C., Stringer, C., Keller, P. J., Beyene, A. G., Chen, Y., Liang, Y., Lavis, L. D., Schreiter, E. R., “A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light” bioRxiv 2023. external pagedoi: 10.1101/2023.07.18.549527call_made
Hellweg, L., Edenhofer, A., Barck, L., Huppertz, M.-C., Frei, M. S., Tarnawski, M., Bergner, A., Koch, B., Johnsson, K., Hiblot, J., “A general method for the development of multicolor biosensors with large dynamic ranges” Nat. Chem. Biol. 2023, 19, 1147-1157. external pagedoi: 10.1038/s41589-023-01350-1call_made
Xue, L., Schnacke, P., Frei, M. S., Koch, B., Hiblot, J., Wombacher, R., Fabritz, S., Johnsson, K. “Probing coenzyme A homeostasis with semisynthetic biosensors” Nat. Chem. Biol. 2023, 19, 346–355. external pagedoi: 10.1038/s41589-022-01172-7call_made
Kompa, J., Bruins, J., Glogger, M., Wilhelm, J., Frei, M. S., Tarnawski, M., D’Este, E., Heilemann, M., Hiblot, J., Johnsson, K. “Exchangeable HaloTag ligands for super-resolution fluorescence microscopy” J. Am. Chem. Soc. 2023, 145, 3075–3083. external pagedoi: 10.1021/jacs.2c11969call_made
2022
Frei, M. S.*, Koch, B., Hiblot, J., Johnsson, K.* “Live-cell fluorescence lifetime multiplexing using synthetic fluorescent probes” ACS Chem. Biol. 2022, 17, 1321–1327. external pagedoi: 10.1021/acschembio.2c00041call_made * Co-corresponding
Frei, M. S., Tarnawski, M., Roberti, M. J., Koch, B., Hiblot, J., Johnsson, K. “Engineered HaloTag variants for fluorescence lifetime multiplexing” Nat. Methods 2022, 19, 65–70. external pagedoi: 10.1038/s41592-021-01341-xcall_made
2019
Frei, M. S., Hoess, P., Lampe, M., Nijmeijer, B., Kueblbeck, M., Ellenberg, J., Wadepohl, H., Ries, J., Pitsch, S., Reymond, L., Johnsson, K. “Photoactivation of silicon rhodamines via a light-induced protonation“ Nat. Commun. 2019, 10, 4580. external pagedoi: 10.1038/s41467-019-12480-3call_made
Wang, L., Frei, M. S., Salim, A., Johnsson, K. “Small-Molecule Fluorescent Probes for Live-Cell Super-Resolution Microscopy” J. Am. Chem. Soc. 2019, 141, 2770–2781. external pagedoi: 10.1021/jacs.8b11134call_made
2017
Schwertz, G., Frei, M. S., Witschel, M. C., Rottmann, M., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schäfer, A., Aponte, R. A., Trapp, N., Mark, K., Chaiyen, P., Diederich, F. “Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs” Chem. Eur. J. 2017, 23, 14345–14357. external pagedoi: 10.1002/chem.201703244call_made
2015
Frei, M. S., Bilyard, M. K., Alanine, T. A., Galloway, W. R. J. D., Stokes, J. E., Spring, D. R. “Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis” Bioorg. Med. Chem. 2015, 23, 2666–2679. external pagedoi: 10.1016/j.bmc.2014.11.037call_made